{"story":{"story_id":90951,"version":1,"published_at":"2026-10-15T18:40:32.640599+00:00","status":"PUBLISHED","title":"Researchers identify key pathway that drives T-cell exhaustion in cancer immunotherapy","summary":"Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.","category":"saglik","source_url":"https://medicalxpress.com/news/2026-10-key-pathway-cell-exhaustion-cancer.html","content_hash":"951a14193e013fe7c7ff1a95f5bdcdffb2abd4221d294c13e1ddf13aa2201989","created_at":"2026-10-15 18:41:17","updated_at":"2026-10-15 18:41:17","language":"en","source_domain":"trthaber.com","source_snapshot_path":"C:\\AYRA\\prod\\app\\data\\snapshots\\00090951_medicalxpress_com.html.gz","source_snapshot_hash":"c5055115f304ec6d491da4e1c668cb0aaa0956ebf1854ddfcda8eaf0a7833fc2","source_snapshot_at":"2026-10-15T18:41:18.305815+00:00","capture_method":"rss","masa_score":0,"masa_tier":"UNRATED","masa_lenses":null,"masa_is_spam":0,"masa_updated_at":null,"admiralty_grade":null,"admiralty_score":0,"confirmation_level":3,"confirmation_sources":0,"lens_count":0,"threat_level":"DUSUK","threat_weight":10,"ach_count":0,"ach_top":null,"scheduled_at":null,"cycle_interval_hours":null,"status_note":null,"updated_by":null,"image_url":"https://scx1.b-cdn.net/csz/news/tmb/2026/researchers-identify-k-6.jpg","independence_group":null,"canonical_id":null,"decision":null},"entities":[{"entity_type":"organization","entity_name":"AB","mentions_count":1}],"related":[{"story_id":90942,"title":"EZB erlaubt UniCredit offenbar Übernahme von Commerzbank","category":"dunya","published_at":"2026-10-15T20:17:00+02:00","relation_type":"SHARED_ENTITY"},{"story_id":90902,"title":"ABD'nin İsrail'de geniş tabanlı bir \"ulusal birlik hükümeti\" kurulması için baskı yaptığı iddia edildi","category":"genel","published_at":"2026-10-15T21:22:50+03:00","relation_type":"SHARED_ENTITY"},{"story_id":90893,"title":"LLM Observability: Tracing Every Step From Prompt to Final Answer","category":"teknoloji","published_at":"2026-10-15T18:10:20+00:00","relation_type":"SHARED_ENTITY"},{"story_id":90890,"title":"When Love Becomes Control","category":"teknoloji","published_at":"2026-10-15T18:12:48+00:00","relation_type":"SHARED_ENTITY"},{"story_id":90888,"title":"AI tool helps identify harmful epilepsy genetic variants","category":"saglik","published_at":"2026-10-15T18:25:32.669652+00:00","relation_type":"SHARED_ENTITY"},{"story_id":90886,"title":"Berliner weiter besorgt wegen Mietmarkt - Was könnte eine Regulierung bringen?","category":"dunya","published_at":"2026-10-15T18:05:29+00:00","relation_type":"SHARED_ENTITY"},{"story_id":90882,"title":"EZB erlaubt UniCredit offenbar Übernahme von Commerzbank-Anteilen","category":"dunya","published_at":"2026-10-15T20:17:00+02:00","relation_type":"SHARED_ENTITY"},{"story_id":90853,"title":"Meta and Apple team up to make Muse AI models run better on Macs","category":"teknoloji","published_at":"2026-10-15T14:15:36-04:00","relation_type":"SHARED_ENTITY"},{"story_id":90848,"title":"Russia open to cooperation in energy sector with Africa — Ambassador","category":"dunya","published_at":"2026-10-15T21:20:51+03:00","relation_type":"SHARED_ENTITY"},{"story_id":90841,"title":"Finlandiya’da Salah’tan resital! İstatistikleri altüst etti","category":"genel","published_at":"2026-10-15T17:44:01+00:00","relation_type":"SHARED_ENTITY"}],"timeline":[{"event_date":"2026-10-15T18:40:32.640599+00:00","event_type":"PUBLICATION","description":"Researchers identify key pathway that drives T-cell exhaustion in cancer immunotherapy"}]}